U.S. Route 22 in Pennsylvania

U.S. Route 22
U.S. Route 22
	US 22 highlighted in red and business routes in blue
Route information
	Maintained by PennDOT and DRJTBC
Length	338.20 mi (544.28 km)
Existed	1926–present
Major junctions
West end	US 22 in Hanover Township
	I-376 concurrency from Robinson Township to Monroeville; I-79 near Carnegie; I-279 / US 19 in Pittsburgh; ; I-76 Toll / Penna Turnpike in Monroeville; I-99 / US 220 in Duncansville; I-81 / US 322 near Harrisburg; I-83 / US 322 in Lower Paxton Township; I-78 concurrency from Fredericksburg to Kuhnsville; ; I-476 Toll / Penna Turnpike NE Extension in South Whitehall Township
East end	US 22 in Easton
Location
Country	United States
State	Pennsylvania
Counties	Washington, Allegheny, Westmoreland, Indiana, Cambria, Blair, Huntingdon, Mifflin, Juniata, Perry, Dauphin, Lebanon, Berks, Lehigh, Northampton
Highway system
	United States Numbered Highway System; List; Special; Divided; Pennsylvania State Route System; Interstate; US; State; Scenic Byways; Legislative;

From Wikipedia, in a visual modern way

U.S. Route 22 (US 22) is an east–west U.S. highway that stretches from Cincinnati, Ohio, in the west, to Newark, New Jersey, in the east. In Pennsylvania, the route runs for 338.20 miles (544.28 km) between the West Virginia state line in Washington County, where it is a freeway through the western suburbs of Pittsburgh, and then all the way to the Pennsylvania-New Jersey state line in the Lehigh Valley at Easton in the east.

The portion from the Pennsylvania Route 66 (PA 66) interchange near Delmont east to the Interstate 81 (I-81) interchange near Harrisburg is the main part of Corridor M of the Appalachian Development Highway System, although a large portion near the center of the route has not yet been upgraded to a four-lane divided highway.^[2]^[3]

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Route description

US 22 eastbound in Colonial Park, east of Harrisburg

US 22 carries multiple names as it progresses across the state, including the William Penn Highway and the Lehigh Valley Thruway. Several sections of the road are freeway, including the Lehigh Valley Thruway.

US 22 crosses into Pennsylvania from West Virginia as the William Penn Highway. It becomes concurrent with US 30 (Lincoln Highway) and then west of Pittsburgh also with I-376, as the Penn Lincoln Parkway. It continues as such through Pittsburgh and beyond the end of the US 30 concurrency, and when I-376 reaches its eastern end at the Pennsylvania Turnpike junction with I-76, US 22 resumes as the William Penn Highway again (with Murrysville as a control city on signs).

It begins the long climb eastwards up the Allegheny Plateau towards the gaps of the Allegheny Front. During the last part of its eastbound ascent, it becomes known as the Admiral Peary Highway from Armagh in Indiana County. It crosses the Eastern Continental Divide in Tunnelhill, where it descends through the Blair Gap and down into the Altoona area along the same valley once used by the historic Allegheny Portage Railroad.

From Duncansville to Mount Union, US 22 is a two-lane road with occasional passing and truck-climbing lanes, and it passes through the business district of Huntingdon, where it is three lanes (one lane each way with a turning lane in the middle). It becomes concurrent with US 522 near Mount Union and remains a two-lane road. The US 522 concurrency continues until Lewistown.

US 22 bypasses the downtown area of Lewistown as a four-lane limited access highway and becomes concurrent with US 322, continuing as a four-lane limited access highway along the Juniata and Susquehanna rivers until Harrisburg. In Harrisburg (with the US 322 concurrency ending at I-81), it continues as North Cameron Street, Arsenal Boulevard, Herr Street, Walnut Street, Jonestown Road, and Allentown Boulevard. In Fredericksburg, US 22 becomes concurrent with I-78 for a 40-mile (64 km) stretch before splitting off on to the Lehigh Valley Thruway.

Lehigh Valley Thruway

US 22 eastbound at the PA 378 interchange in Bethlehem

The Lehigh Valley Thruway is a 24-mile-long (39 km) freeway portion of US 22 from the eastern end of the I-78/US 22 concurrency in Kuhnsville, west of Allentown, to the New Jersey state line in Easton. The highway runs through the Lehigh Valley, traveling just to the north of Allentown and Bethlehem and passing through Easton.

Traffic on the Lehigh Valley Thruway is often heavy at rush hour, particularly near the PA 145 interchange in Whitehall Township. The series of sharp curves is locally known as "Cemetery Curve", and because of it, the speed limit is lowered to 45 mph at PA 248 and then lowered to 35 mph around the sharpest part of the curves. At the interchange with Bushkill Street, US 22 becomes an elevated highway until crossing into New Jersey. The speed limit drops once again to 25 mph while crossing the Easton–Phillipsburg Toll Bridge.

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History

US 22 westbound past the 15th Street interchange in South Whitehall Township in the Lehigh Valley

The William Penn Highway was organized as an alternative to the Lincoln Highway being parallel to the Pennsylvania Railroad west of Harrisburg. The route's New York Extension was adopted in 1916. The Pennsylvania Department of Highways assigned the PA 3 designation to this road in 1924, and in 1926 it became part of US 22 when the United States Highway System was formed.^[4]

East of Harrisburg

The first alignment of the William Penn Highway became problematic for motorists in Lebanon along the current US 422; Reading via US 22 and US 222 and Allentown on Hamilton Street (present-day PA 222).^[6] The highway continued through Allentown on Hanover Avenue and through Bethlehem on Broad Street, Linden Street, and Easton Avenue.

PA 43 was aligned as a bypass, north of the Pennsylvania Dutch Country, that ran from US 22, US 11, and PA 5 in Harrisburg east to PA 12 in Bethlehem.^[7] From Harrisburg, this route followed modern-day US 22 to Paxtonia, then Jonestown Road to Jonestown and modern-day Old Route 22, Airport Road, and Main Street through Fredericksburg. East of here to Fogelsville, the route is variously called Old Route 22, Shartlesville Road, and Hex Highway. The route from Fogelsville to the Allentown line, now Main Street and Tilghman Street, was designated LR 443 in 1925^[8] before being incorporated into this route.^[9] The route entered Harrisburg by Liberty Street and connected with the William Penn Highway through 17th Street. The New York Times was recommending use of this cutoff by early 1931.^[9] On June 8, 1931, the American Association of State Highway Officials came to a resolution for the traffic problem, by replacing the PA 43 corridor with US 22. The Pennsylvania Department of Highways moved the William Penn Highway name to match.^[4]^[6] The state deleted a concurrency with PA 43 and what was then US 309 and truncated PA 43 to Susquehanna Street and Broadway from Allentown to Bethlehem.^[10] Signs were changed to reflect the new designations on May 31, 1932, with the new route designations officially in place on June 1, 1932.^[11]

Tilghman Street was eventually connected directly from Cetronia to Allentown by a bridge over Cedar Creek; Tilghman Street (west of the Lehigh River) and Union Boulevard (east of the river) were joined in 1929 by a bridge. By 1936, US 22 had been moved from its Hamilton Street and Broad Street alignment to Tilghman Street and Union Boulevard through Allentown and Bethlehem. From Bethlehem to Easton, an alternate route was formed along Goepp Street, Pembroke Road, and Freemansburg Avenue. With the construction of a new bridge over the Delaware River in 1938, Prospect Avenue, Pearl Street, and Snyder Street in Easton were incorporated into US 22.^[12] A new alignment from Fredericksburg to Paxtonia was built in the early 1940s. When the Lehigh Valley Thruway was completed in 1954, US 22 was moved onto it; its old alignment was redesignated State Route 1002 through Lehigh County. With the completion of I-78, US 22 was moved onto that highway from Fredericksburg to Kuhnsville. The former alignment, although no longer a major state highway, is still well traveled by those who live in the vicinity.

Originally, I-78 would have continued with the US 22 concurrency on the Lehigh Valley Thruway into New Jersey, and I-178 and I-378, serving Allentown and Bethlehem, respectively. Due to opposition in Phillipsburg, New Jersey, on the building of a new highway through the town, PennDOT and NJDOT decided to reroute I-78 to the south and allow US 22 to remain on the limited-access highway, which, after going through a series of sharp, potentially dangerous curves in Easton and crossing the Delaware River into New Jersey, becomes an at-grade divided highway in Phillipsburg.

West of Harrisburg

Two-lane section of US 22, west of Nanty Glo in 2006; this section was widened to four lanes by 2011.

The origins of this section of US 22 date back to the early 1800s, with the chartering of the Harrisburg, Lewistown, Huntingdon and Pittsburgh Turnpike in 1807, following the course of what would become US 22 from Harrisburg to Pittsburgh,^[13] providing a more northerly alternative to the Harrisburg and Pittsburgh Turnpike chartered the year prior. Support for the turnpike was lacking along its route, and so to foster a sense of locality to the road the company was broken up in the subsequent years into five sections: the Huntingdon, Cambria, and Indiana in 1810 (terminating at Huntingdon and Blairsville); the New Alexandria and Conemaugh in 1816 (Blairsville to New Alexandria); the Pittsburgh and New Alexandria Turnpike in 1816; and the Harrisburg and Millerstown, Millerstown and Lewistown, and Lewistown and Huntingdon Turnpikes in 1821. In their own times, these companies constructed a highway across the Appalachians collectively called the Northern Pike, but all folded with competition from the Main Line of Public Works, and later the Pennsylvania Railroad.

In its earliest years, US 22 deviated from the original course of the William Penn Highway in a few notable places. With the construction of the Boulevard of the Allies in the early 1920s, the highway was rerouted to service this thoroughfare. This alignment entered Pittsburgh on modern day PA 8, then made its way downtown by Dallas Avenue, Wilkins Avenue, Beeler Street, Forbes Street, the Boulevard of the Allies, and Second Street. The highway then followed the old Pittsburgh and Steubenville Pike to Ohio. With the construction of the Penn-Lincoln Parkway in the late 1950s, both US 22 and US 30 were shifted to the new highway.

Further east, where the William Penn Highway deviated from the Northern Pike between Ebensburg and Water Street to service Altoona and Tyrone, the Northern Pike was restored as the main east–west thoroughfare, while US 220 was chosen to service these cities. A few notable deviations from this include Turkey Valley Road near Canoe Creek Lake, and a bend servicing Williamsburg via modern-day PA 866 and SR 2015, which both deviated from the Northern Pike.^[14] These were later christened as PA 303 and PA 203 respectively when the highway was restored to the Northern Pike.^[7] Near the Susquehanna River, before an alignment along the Juniata River had been constructed, the highway serviced New Bloomfield and Meck's Corner by modern-day PA 34 and PA 274; while US 22 was shifted north, this alignment still held its old designation of PA 3 for some time afterwards.^[7]

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Future

In 2011, it was announced that plans were being resurrected to widen US 22 from Allentown to Bethlehem. Part of the plan is to reconstruct the Lehigh River Bridge. The plan's cost is between $240 million to $320 million.^[15] In late 2019, plans to study a potential upgrade to an interstate were announced since additional federal funding is available for interstate construction.

Major intersections

County	Location	mi	km	Exit	Destinations	Notes
Washington	Hanover Township	0.00	0.00		US 22 west – Weirton	West Virginia border
	Hanover Township	5.3	8.5		PA 18 – Florence, Burgettstown	Access to Raccoon Creek State Park and The Pavilion at Star Lake
	Robinson Township	9.7	15.6		Bavington	Access via Maple Grove Road
	Robinson Township	11.4	18.3		PA Turnpike 576 to I-79 – Pittsburgh International Airport, Washington	PA 576 exit 6; E-ZPass or toll-by-plate
Allegheny	North Fayette Township	12.8	20.6		PA 980 south – McDonald, Midway	Northern terminus of PA 980
		14.4	23.2		Noblestown	Access via Kelso Road; access to Pennsylvania Motor Speedway
		16.0	25.7		US 30 west / PA 978 south – Imperial	Western terminus of US 30 concurrency; western terminus of Penn-Lincoln Parkway (Parkway West); northern terminus of PA 978; access to Raccoon Creek State Park
		17.4	28.0		Hankey Farms	Access via Oakdale Road
		18.4	29.6		Orange Belt (Oakdale)	Westbound exit and eastbound entrance; western terminus of Orange Belt concurrency
		19.5	31.4		Montour Church Road / Old Steubenville Pike / Bayer Road	Westbound exit and eastbound entrance
	Robinson Township	19.9	32.0		I-376 west / PA 60 south / Orange Belt – Airport, Crafton	Partial cloverleaf interchange; western terminus of I-376 concurrency, US 22 not posted on guide signs until Wilkinsburg; exit 60A from westbound I-376; eastern terminus of Orange Belt concurrency; no access to PA 60 from westbound US 22
		20.4	32.8	60B	To PA 60 south – Crafton	To northern terminus of PA 60; separate single ramp from partial cloverleaf
		20.7	33.3	61	Ridge Road
	Robinson–Collier township line	21.9	35.2	62	Yellow Belt (Campbells Run Road)	Westbound exit and eastbound entrance
	Robinson Township	23.5	37.8	64A	I-79 – Washington, Erie	I-79 exit 59
	Rosslyn Farms	24.3	39.1	64B	Rosslyn Farms	Westbound exit and eastbound entrance; access via Rosslyn Road
	Carnegie	24.8	39.9		Buses only (West Busway)	Eastbound exit and westbound entrance
	Carnegie	25.2	40.6	65	PA 50 – Carnegie, Heidelberg
	Green Tree	27.0	43.5	67	PA 121 – Green Tree, Mount Lebanon, Crafton
	Pittsburgh	27.6	44.4	68	Parkway Center Drive	Westbound exit and eastbound entrance
		28.2	45.4	69A	US 19 south (Banksville Road)	Western termini of US 19 and unsigned US 19 Truck concurrencies; eastbound exit is via exit 69C
		28.7	46.2	69B	US 19 Truck south / PA 51 south – Uniontown	Westbound exit is via exit 69A
		28.7	46.2	69C	US 19 north / PA 51 north – West End	Eastern terminus of US 19 concurrency; eastbound exit and westbound entrance
		29.1	46.8	Fort Pitt Tunnel under Mount Washington
		29.6	47.6	69C	PA 837 to PA 51 – West End	Westbound exit and eastbound entrance
	Monongahela River	29.7	47.8	Fort Pitt Bridge
	Pittsburgh	29.7	47.8	70A	Boulevard of the Allies / Liberty Avenue – PPG Paints Arena	Eastbound exit and westbound entrance
		29.7	47.8	70B	Fort Duquesne Boulevard – Convention Center, Strip District	Eastbound exit and westbound entrance
		29.7	47.8	70C	I-279 / US 19 Truck north – Fort Duquesne Bridge, North Shore	Eastern terminus of unsigned US 19 Truck concurrency; Parkway West becomes Parkway East
		30.0	48.3	70D	Stanwix Street	No eastbound exit
		30.4	48.9	71A	Grant Street
		30.9	49.7	71B	Second Avenue	Westbound exit only
		31.8	51.2	72A	Forbes Avenue – Oakland	Eastbound exit and westbound entrance
		32.1	51.7	72B	To I-579 (Crosstown Blvd) / PA 885 north (Boulevard of the Allies) / Liberty Bridge	Westbound exit and eastbound entrance; access to I-579 and Liberty Bridge is via Boulevard of the Allies
		32.6	52.5	73	PA 885 (Bates Street) – Oakland, Glenwood	Westbound exit and eastbound entrance; signed as exits 73A (south) and 73B (north)
		34.2	55.0	74	Blue Belt – Squirrel Hill, Homestead
		34.8	56.0	Squirrel Hill Tunnel under Squirrel Hill
	Pittsburgh–Swissvale– Edgewood tripoint	36.4	58.6	77	Edgewood, Swissvale	Access via Braddock Avenue
	Wilkinsburg	37.7	60.7	78A	US 30 east – Forest Hills	Eastern terminus of US 30 concurrency; US 22 once again posted on guide signs; no westbound exit
	Wilkinsburg	37.9	61.0	78B	PA 8 north – Wilkinsburg	Southern terminus of PA 8
	Churchill	38.6	62.1	79A	Greensburg Pike	Eastbound exit and westbound entrance
		39.1	62.9	79B	PA 130 – Churchill
		39.9	64.2	80	US 22 Bus. east – Monroeville	Eastbound exit and westbound entrance
		40.2	64.7	81	PA 791 north / Yellow Belt – Penn Hills
	Monroeville	43.8	70.5	84A	PA 48 south / Orange Belt – Monroeville	Eastbound exit and westbound entrance; northern terminus of PA 48
		44.0	70.8	84B	Orange Belt – Plum	Eastbound exit and westbound entrance
		44.3	71.3	85	I-76 / Penna Turnpike / US 22 Bus. west – Monroeville, Ohio, Harrisburg	Eastern terminus of I-376 and Penn-Lincoln Parkway (Parkway East); unnumbered exit westbound; westbound exit and eastbound entrance to US 22 Bus; E-ZPass or toll-by-plate on Penna Turnpike
		44.5	71.6	Eastern terminus of freeway
		46.4	74.7		PA 286 east (Golden Mile Highway)	Eastbound exit and westbound entrance, westbound exit and eastbound entrance provided by at-grade intersection; western terminus of PA 286
Westmoreland	Salem Township	54.8	88.2		PA 66 to PA Turnpike 66 – Delmont, Greensburg	Single-point urban interchange
		57.4	92.4		PA 819 – Slickville, Forbes Road, Greensburg
		61.8	99.5		US 119 south – Greensburg	Western terminus of US 119 concurrency
	New Alexandria–Derry Township line	62.8	101.1		PA 981 (Latrobe New Alexandria Road) – Latrobe, Saltsburg
	Derry Township	67.3	108.3		PA 982 south – Derry	Northern terminus of PA 982
Indiana	Blairsville	71.5	115.1		PA 217 – Blairsville, Derry	Interchange
	Burrell Township	74.2	119.4		US 119 north – Homer City, Indiana	Interchange; eastern terminus of US 119 concurrency; access to Indiana University of Pennsylvania
	West Wheatfield Township	80.3	129.2		PA 259 – Brush Valley, Robinson, Bolivar	Interchange
	East Wheatfield Township			Western terminus of freeway
		84.4	135.8		PA 56 – Brush Valley, Armagh	Access to Johnstown
					East Philadelphia Street	Eastbound exit and entrance
		85.6	137.8		PA 403 – Dilltown, Johnstown
				Eastern terminus of freeway
Cambria	Jackson Township				Dishong Mountain Road	Interchange
	Jackson Township	95.2	153.2		PA 271 – Mundys Corner, Nanty Glo	Interchange
	Cambria Township	99.5	160.1		US 219 to US 422 – Johnstown, Carrolltown, Indiana	Interchange
		100.9	162.4		Ebensburg	Interchange; no westbound exit; access via High Street
		102.8	165.4	Western terminus of freeway
		102.8	165.4		Ebensburg, Loretto	Access via Rowena Drive/Admiral Peary Highway
	Munster Township	105.9	170.4		PA 164 south – Munster, Portage	Northern terminus of PA 164
	Cresson Township	109.0	175.4		PA 53 – Cresson, Lilly, Portage	Cresson signed eastbound; Portage signed westbound; access to Mount Aloysius College and Prince Gallitzin State Park
	Cresson Township	111.1	178.8		Cresson, Summit	Access via Admiral Peary Highway; Cresson signed westbound; access to Mount Aloysius College and Prince Gallitzin State Park
Cambria–Blair county line	Cresson–Allegheny township line	112.8	181.5		Gallitzin	Access via Tunnelhill Road; access to Allegheny Portage Railroad National Historic Site
Blair	Allegheny Township	119.2	191.8		I-99 / US 220 – Altoona, Bedford	I-99/US 220 exit 28
		120.2	193.4		PA 764 north – Altoona	Southern terminus of PA 764
		120.2	193.4	Eastern terminus of freeway
		121.8	196.0		US 220 Bus. south (Old US 220) to I-99 south / US 220 south – Newry, Bedford	Western terminus of US 220 Bus. concurrency
	Blair Township				US 220 Bus. north (Plank Road) to I-99 / US 220 – Altoona	Eastern terminus of US 220 Bus. concurrency
	Hollidaysburg	124.6	200.5		PA 36 (Penn Street) – Altoona, Roaring Spring
	Frankstown Township	136.3	219.4		PA 866 south (Juniata River Road) – Williamsburg	Northern terminus of PA 866
Huntingdon	Morris Township	142.0	228.5		PA 453 north (Birmingham Pike) to PA 45 – Tyrone, State College	Southern terminus of PA 453
	Porter Township	144.6	232.7		PA 305 east (Bridge Street) – Alexandria	Western terminus of PA 305
	Smithfield Township	150.2	241.7		PA 26 – Everett, Huntingdon, State College	Interchange
	Smithfield Township				Fairgrounds Road	Interchange
	Henderson Township				To PA 26 north – Huntingdon, State College	Interchange; access via Penn Street
	Henderson Township	156.4	251.7		PA 829 south – Cassville	Northern terminus of PA 829
	Mill Creek	157.2	253.0		PA 655 north – Belleville	Western terminus of PA 655 concurrency
	Brady Township	158.6	255.2		PA 655 south (Oriskany Road) – Mapleton, Saltillo	Eastern terminus of PA 655 concurrency
Mifflin	Wayne Township	163.1	262.5		PA 747 south (North Jefferson Street) – Mount Union	Northern terminus of PA 747
	Wayne Township	163.5	263.1		US 522 south (Croghan Pike) – Orbisonia	Western terminus of US 522 concuurency
	Granville Township	182.2	293.2	Western terminus of freeway
	Granville Township	182.2	293.2		US 22 Bus. east	Western terminus of US 22 Bus.
	Derry Township	186.2	299.7		US 322 west – State College	Western terminus of US 322 concurrency
	Derry Township	186.4	300.0		Electric Avenue
	Lewistown	187.0	300.9		US 522 north (Walnut Street) – Selinsgrove	Eastern terminus of US 522 concurrency
	Derry Township	187.4	301.6		East Charles Street	Eastbound exit and westbound entrance
	Derry Township	189.3	304.6		US 22 Bus. west – Lewistown	Westbound exit and eastbound entrance; eastern terminus of US 22 Bus.
Juniata	Fermanagh Township				Fishing/Boating Access Area	Eastbound exit and entrance
		196.9	316.9		Arch Rock Road
		200.1	322.0		PA 35 – Mifflintown, McAlisterville	Access to Mifflintown Airport
	Walker Township	202.0	325.1		PA 75 south – Port Royal	Northern terminus of PA 75
	Delaware Township–Thompsontown line	209.6	337.3		PA 333 – East Salem, Thompsontown
	Delaware Township	211.2	339.9		Pfoutz Valley Road	Westbound exit and eastbound entrance
Perry	Greenwood Township	215.0	346.0		To PA 17 – Millerstown	Access via West Juniata Parkway
	Howe Township	219.5	353.3		PA 34 – Newport, New Bloomfield	Access to Little Buffalo State Park
	Buffalo Township	223.3	359.4		Midway	Westbound exit and eastbound entrance; access via Meadow Grove Road
	Watts Township	225.9	363.6		Watts	Left exit eastbound; right exit westbound; access via Huggins Road
	Watts Township	227.8	366.6		Amity Hall	Access via River Road
Dauphin	Reed Township	228.0	366.9		US 11 / US 15 – Camp Hill, Selinsgrove
				Eastern terminus of freeway
		229.4	369.2		PA 849 west – Duncannon	Eastern terminus of PA 849; no access from PA 849 to US 22/US 322 westbound
				Western terminus of freeway
	Susquehanna River			Clarks Ferry Bridge
	Reed Township	229.8	369.8		PA 147 north – Halifax	Southern terminus of PA 147
	Middle Paxton Township	231.8	373.0		PA 325 east (Mountain Road)	Western terminus of PA 325
	Middle Paxton Township	235.2	378.5		PA 225 north – Halifax, Dauphin	Southern terminus of PA 225
	Dauphin	236.2	380.1		Dauphin Borough, Stony Creek	Westbound exit; access via Allegheny Street
	Middle Paxton Township	237.6	382.4		PA 443 – Fishing Creek, Rockville	Rockville signed eastbound
	Susquehanna Township–Harrisburg line	239.5	385.4		PA 39 – Linglestown, Rockville	Rockville signed westbound
	Harrisburg	241.5	388.7		I-81 south (Capital Beltway) – Carlisle I-81 north / US 322 east (Capital Beltway) to I-78 / I-83 – Hershey, Hazleton, Allentown	I-81 exit 67; eastern terminus of US 322 concurrency; I-83 and Hershey signed eastbound, I-78 and Hazleton signed westbound
				Eastern terminus of freeway
					PA 230 east (Cameron Street)	Western terminus of PA 230
	Lower Paxton Township				I-83 / US 322 (Capital Beltway) to I-81 – Carlisle, Hazleton, Hershey, York	I-83/US 322 exit 50
	West Hanover Township				PA 39 (Hershey Road) to I-81 – Hershey
	East Hanover Township				PA 743 south (Laudermilch Road) to I-81 – Grantville, Hershey	Northern terminus of PA 743
Lebanon	East Hanover Township				PA 934 to I-81 – Annville, Fort Indiantown Gap	Interchange
	Union Township				PA 72 to I-81 – Lebanon, Lickdale	Cloverleaf interchange
	Bethel Township				PA 343 south (Pine Grove Street) – Lebanon	Western terminus of PA 343 concurrency
					PA 343 north (Pine Grove Road) to I-78 west	Eastern terminus of PA 343 concurrency
					Local Traffic	Old US 22 to Mount Zion Road
				Western terminus of freeway
				–	I-78 west – Harrisburg	Westbound exit and eastbound entrance; western terminus of I-78 concurrency; US 22 continuation signed as I-78 exit 8
Berks	Bethel Township			10	PA 645 – Frystown
				13	PA 501 – Bethel
				15	Grimes	No access across I-78/US 22; no tractor trailers
				16	Midway
				17	PA 419 – Rehrersburg	Access to Conrad Weiser Homestead
	Upper Tulpehocken Township			19	PA 183 – Strausstown
	Upper Bern Township			23	Shartlesville
	Tilden Township			29	PA 61 – Pottsville, Reading
	Hamburg			30	Hamburg
	Greenwich Township			35	PA 143 – Lenhartsville
	Greenwich Township			40	PA 737 – Kutztown, Krumsville	Access to Kutztown University
Lehigh	Weisenberg Township			45	PA 863 – Lynnport, New Smithville
	Upper Macungie Township			49	PA 100 – Trexlertown, Fogelsville	Split into exits 49A (south) and 49B (north)
				–	I-78 east – New Jersey	Eastbound exit and westbound entrance; eastern terminus of I-78 concurrency; US 22 continuation signed as I-78 exit 51
		315.7	508.1		Cetronia, Kuhnsville	Access via SR 1002 (Tilghman Street), former routing of US 22 through Allentown
	South Whitehall Township	316.1	508.7		I-476 Toll / Penna Turnpike NE Extension – Scranton, Philadelphia	I-476 / Penna Turnpike NE Extension exit 56 (Lehigh Valley); E-ZPass or toll-by-plate
		316.7	509.7		PA 309 – Quakertown, Tamaqua	Cloverleaf interchange; access to I-78 east, Dorney Park & Wildwater Kingdom, and Lehigh Carbon Community College
		318.7	512.9		Cedar Crest Boulevard	Access to Muhlenberg College and Cedar Crest College
		320.3	515.5		15th Street	Parclo A2 interchange; access to 15th Street via Mauch Chunk Road
	Whitehall Township	321.0	516.6		PA 145 (MacArthur Road/7th Street)	Access to Allentown Center City, Lehigh Valley Mall, and Whitehall Mall
	Whitehall Township	322.1	518.4		Fullerton Avenue
	Hanover Township–Bethlehem line	324.0	521.4		PA 987 north (Airport Road) – LVI Airport	Cloverleaf interchange; southern terminus of PA 987
	Bethlehem	325.1	523.2		PA 378 south – Bethlehem	Northern terminus of PA 378; access to Lehigh University, Historic Bethlehem, Wind Creek Bethlehem; formerly I-378
Northampton	Bethlehem	325.6	524.0		Schoenersville Road
	Hanover Township	327.4	526.9		PA 512 north (Center Street)	Southern terminus of PA 512; access to Moravian University
	Bethlehem Township	329.9	530.9		PA 191 north (Nazareth Pike)	Southern terminus of PA 191; access to Northampton Community College
	Bethlehem Township	332.3	534.8		PA 33 to I-78 – Bethlehem, Stroudsburg	Cloverleaf interchange
	Palmer Township	334.5	538.3		PA 248 (25th Street) – Wilson	Access to Palmer Heights and Easton
	Easton	336.0	540.7		13th Street	Parclo B3 interchange; access to 13th Street via Wood Avenue
		337.5	543.2		4th Street to PA 248 / PA 611	Eastbound exit and westbound entrance
		337.8	543.6		3rd Street / Snyder Street – Easton, Lafayette College	Westbound exit and eastbound entrance
		337.9	543.8		PA 611	Westbound exit and eastbound entrance
Delaware River				Easton–Phillipsburg Toll Bridge (Westbound toll, cash or E-ZPass)
Delaware River					US 22 east to I-78 – Phillipsburg	Continuation into New Jersey
1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus Electronic toll collection Incomplete access Tolled

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Source: "U.S. Route 22 in Pennsylvania", Wikipedia, Wikimedia Foundation, (2023, March 19th), https://en.wikipedia.org/wiki/U.S._Route_22_in_Pennsylvania.