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Herbert M. Sauro

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Herbert M. Sauro
BornJuly 1960 (age 62)
Dyfed, Wales
NationalityBritish, USA
Alma materOxford Brookes University
Known formetabolic control analysis, metabolic regulation, SBML
Scientific career
FieldsBiochemistry, systems biology
InstitutionsUniversity of Edinburgh, Keck Graduate Institute, University of Washington
ThesisControl analysis and simulation of metabolism (1986)
Academic advisorsDavid Fell

Herbert M. Sauro works in the field of metabolic control analysis and systems biology.

Education and early life

Sauro was born July 19, 1960 in Dyfed, Wales. He grew up in the village of Llangolman in Pembrokeshire and attended the welsh comprehensive school Ysgol y Preseli.[1]

Education

After obtaining a B.Sc. in biochemistry with microbiology at the University of Canterbury and an M.Sc. in biological computing at the University of York, Sauro moved to Oxford Brookes University for his Ph.D. (1986) under the direction of David Fell, for a thesis entitled Control analysis and simulation of metabolism, work that led to several publications, including one in which new relationships between elasticities and control coefficients were described.[2] Subsequently he obtained a teaching degree at the University of Aberystwyth.

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Research

Sauro carried out post-doctoral research at the University of Edinburgh in association with Henrik Kacser, when he worked on time-dependent systems[3] and enzyme-enzyme interactions.[4][5]

While a student at Oxford Sauro wrote a program called SCAMP for modelling metabolic systems,[6] later developed as Jarnac[7] and incorporated in his Systems Biology Workbench.[8]

Together with Hamid Bolouri, Andrew Finney and Michael Hucka he was a member of the development team for the creation of SBML (the Systems Biology Mark-up language),[9] which has become a major influence on the subject.[10]

Books

Sauro is the author of books on metabolic control analysis,[11] enzyme kinetics,[12] and Laplace transforms,[13]

Source: "Herbert M. Sauro", Wikipedia, Wikimedia Foundation, (2023, January 29th), https://en.wikipedia.org/wiki/Herbert_M._Sauro.

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References
  1. ^ ORCID 0000-0002-3659-6817
  2. ^ Fell, D A; Sauro, H M (1985). "Metabolic control and its analysis: additional relationships between elasticities and control coefficients". Eur. J. Biochem. 148 (3): 555–561. doi:10.1111/j.1432-1033.1985.tb08876.x. PMID 3996393.
  3. ^ Acerenza, L; Sauro, H M; Kacser, H (1989). "Control analysis of time-dependent metabolic systems". J. Theor. Biol. 137 (4): 423–444. Bibcode:1989JThBi.137..423A. doi:10.1016/S0022-5193(89)80038-4. PMID 2626059.
  4. ^ Kacser, H; Sauro, H M; Acerenza, L (1990). "Enzyme-enzyme interactions and control analysis. 1. the case of nonadditivity - monomer-oligomer associations". Eur. J. Biochem. 187 (3): 481–491. doi:10.1111/j.1432-1033.1990.tb15329.x. PMID 2406132.
  5. ^ Sauro, H M; Kacser, H (1990). "Enzyme-enzyme interactions and control analysis. 2. The case of nonindependence - heterologous association". Eur. J. Biochem. 187 (3): 493–500. doi:10.1111/j.1432-1033.1990.tb15330.x. PMID 2406133.
  6. ^ Sauro, H M (1993). "SCAMP: a general-purpose simulator and metabolic control analysis programs". Comput. Appl. Biosci. 9 (4): 441–450. doi:10.1093/bioinformatics/9.4.441. PMID 8402211.
  7. ^ Sauro, H M (2000). "Jarnac: a system for interactive metabolic analysis". In Hofmeyr, J.-H.S.; Rohwer, J. M; Snoep, J. L (eds.). Animating the Cellular Map. Stellenbosch University Press. pp. 221–228. ISBN 0-7972-0776-7.
  8. ^ Wellock, C; Chickarmane, V; Sauro, H M (2005). "The SBW-MATLAB Interface". Bioinformatics. 21 (6): 823–824. doi:10.1093/bioinformatics/bti110. PMID 15531613.
  9. ^ Hucka, M.; Finney, A.; Sauro, H. M.; Bolouri, H.; Doyle, J. C.; Kitano, H.; Arkin, A. P.; Bornstein, B. J.; Bray, D; Cornish-Bowden, A.; Cuellar, A. A.; Dronov, S.; Gilles, E.D.; Ginkel, M; Gor, V.; Goryanin, I.I.; Hedley, W.J.; Hodgman, T. C.; Hofmeyr, J. -H.; Hunter, P. J.; Juty, N. S.; Kasberger, J. L.; Kremling, A.; Kummer, U.; Le Novère, N.; Loew, L. M.; Lucio, D.; Mendes, P.; Minch, E.; Mjolsness, E.D.; Nakayama, Y.; Nelson, M.R.; Nielsen, P. F.; Sakurada, T.; Schaff, J. C.; Shapiro, B.E.; Shimizu, T. S.; Spence, H. D.; Stelling, J.; Takahashi, K.; Tomita, M.; Wagner, J.; Wang, J. (2003). "The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models". Bioinformatics. 19 (4): 524–531. doi:10.1093/bioinformatics/btg015. PMID 12611808.
  10. ^ More than 2000 citations as of early 2023.
  11. ^ Sauro, H M (2018). Systems Biology: An Introduction to Metabolic Control Analysis (2nd ed.). ISBN 978-0982477366.
  12. ^ Sauro, H M (2023). Enzyme Kinetics for Systems Biology (2nd ed.). Ambrosius Publishing. ISBN 978-0982477335.
  13. ^ Sauro, H M (2021). The Little Book of Laplace Transforms. Ambrosius Publishing. ISBN 978-1732548619.
  14. ^ https://depts.washington.edu/bpsd/people/faculty/sauro/
  15. ^ "Center for Reproducible Biomedical Modeling". Center for Reproducible Biomedical Modeling.

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