EMD GP38AC

The Grand Trunk Western Railroad Company was an American subsidiary of the Canadian National Railway operating in Michigan, Illinois, Indiana, and Ohio. Since a corporate restructuring in 1971, the railroad has been under CN's subsidiary holding company, the Grand Trunk Corporation. Grand Trunk Western's routes are part of CN's Michigan Division. Its primary mainline between Chicago and Port Huron, Michigan serves as a connection between railroad interchanges in Chicago and rail lines in eastern Canada and the Northeastern United States. The railroad's extensive trackage in Detroit and across southern Michigan has made it an essential link for the automotive industry as a hauler of parts and automobiles from manufacturing plants.

The Gulf, Mobile and Ohio was a Class I railroad in the central United States whose primary routes extended from Mobile, Alabama, and New Orleans, Louisiana, to St. Louis and Kansas City, Missouri, as well as Chicago, Illinois.

The Illinois Central Railroad, sometimes called the Main Line of Mid-America, was a railroad in the Central United States, with its primary routes connecting Chicago, Illinois, with New Orleans, Louisiana, and Mobile, Alabama, and thus, the Great Lakes to the Gulf of Mexico. A line also connected Chicago west to Sioux City, Iowa (1870). There was a significant branch to Omaha, Nebraska (1899), west of Fort Dodge, Iowa, and another branch reaching Sioux Falls, South Dakota (1877), starting from Cherokee, Iowa.

Conrail, formally the Consolidated Rail Corporation, was the primary Class I railroad in the Northeastern United States between 1976 and 1999. The trade name Conrail is a portmanteau based on the company's legal name. It continues to do business as an asset management and network services provider in three Shared Assets Areas that were excluded from the division of its operations during its acquisition by CSX Corporation and the Norfolk Southern Railway.

The Louisville and Nashville Railroad, commonly called the L&N, was a Class I railroad that operated freight and passenger services in the southeast United States.

The Seaboard System Railroad, Inc. was a US Class I railroad that operated from 1982 to 1986.

The Norfolk and Western Railway, commonly called the N&W, was a US class I railroad, formed by more than 200 railroad mergers between 1838 and 1982. It was headquartered in Roanoke, Virginia, for most of its existence. Its motto was "Precision Transportation"; it had a variety of nicknames, including "King Coal" and "British Railway of America". In 1986, N&W merged with Southern Railway to form today’s Norfolk Southern Railway.

The Norfolk Southern Railway is a Class I freight railroad operating in the Eastern United States. Headquartered in Atlanta, the company was formed in 1982 with the merger of the Norfolk and Western Railway and Southern Railway. The company operates 19,420 route miles in 22 eastern states, the District of Columbia, and had rights in Canada over the Albany to Montréal route of the Canadian Pacific Railway. Norfolk Southern Railway is the leading subsidiary of the Norfolk Southern Corporation.

The Southern Railway was a class 1 railroad based in the Southern United States between 1894 and 1982, when it merged with the Norfolk & Western to form Norfolk Southern. The railroad was the product of nearly 150 predecessor lines that were combined, reorganized and recombined beginning in the 1830s, formally becoming the Southern Railway in 1894.

The Burlington Northern Railroad was a United States-based railroad company formed from a merger of four major U.S. railroads. Burlington Northern operated between 1970 and 1996.